I every day carry a LCP II or Glock 43. 95% of the time I use a IWB holster, and if concealment requirements dictate...I will pocket carry the LCP II in the holster Ruger provided with the weapon. I always carry with a round in the chamber (I will post a link to a good video below that I think illustrates why that is imperative for me). Personal choice I know, but it literally could be a life or death decision. I would not use not carrying a round in the LCP II as a mitigation for the lack of manual safety and lighter trigger pull. For the record, even though I do EDC with the LCP II and Glock 43 I think the "trigger safety" feature both advertise is a bit of a stretch. That is like putting a "safety" on your accelerator pedal of you car...you press down on the accelerater you are going to speed up regardless if there is a "safety switch" in front of the pedal.
So, I'm comfortable carrying these style weapons because I train constantly and I practice the rules of gun safety religiously. When holstering my weapon, or if I had to draw my weapon for any reason, I do or will not try win any speed records getting the weapon in or back in the holster.
Here's the link to the video I mentioned. Good demonstration of why I carry with a round in the chamber. Regardless of your thoughts on the LCP II, manual safeties, and single action/light trigger pulls...I would agree that carrying without a round in the chamber significantly decreases your ability to defend yourself in a defensive gun use situation when somebody rushes at you.